ELISA method is known to be one of the modern techniques used in medicine and biology to detect pathogens such as viruses, bacteria, fungi, parasites, etc. Although used quite common, but this technique is still the main disadvantages: result in long, low sensitivity, lack of functional separation of molecules have been measured and especially an ELISA very expensive. The idea to create a cheaper device, measure the concentration and separation of specific biological molecules, to overcome the disadvantages of ELISA was TS meter. High Xuan Organic simmering since he is a graduate student in Korea. This idea initially seems very "adventurous". But with his knowledge and experience, Dr.. Spring Friendship and young team convinced the scientific council for the execution of potential, "Research on the measurement system and separation of biomolecules specific protein / DNA."

In principle, measuring equipment using magnetic nanoparticles (with diameter size from 5 to 100nm) as an intermediate agent for measurement. The process used is expected to be carried out in three steps: (i) attached to specific biological molecules onto magnetic nanoparticles; (ii) measuring the concentration of biological molecules through the nanoparticles; (iii) separating biological molecules from the nanoparticles. The choice of coating creates a link on the surface (surface activation) of nanoparticles in accordance with the specific biomolecules (antibodies, antigens or protein / DNA) and molecular techniques to attach This biological nanoparticles have been extensively studied in the world. The separation of biological molecules are attached from the magnetic nanoparticles can also be referenced from many previous studies. Key issues that researchers need to address is creating the ultra-sensitive bio-sensing and electronic signal processing system to produce accurate data on levels of biological molecules has been associated nanoparticles. The design and manufacture of the magnet system with electronic control circuit as well as information processing measured signal is not difficult for young researchers. However, the creation of the first receiver (sensor) ultra-sensitive biomagnetic sensors is a challenge for the team. This type of sensor is not available on the market and Vietnam did not have the ability to create. To solve this difficulty, after landing configuration design of the sensor body chair theme, TS. Cao Xuan Friends, have to take South Korea to coordinate with his former colleagues to make.
Another problem posed is: to be able to measure the tiny magnetic field (about 10-5 compared with the Earth's magnetic field) of the nanoparticles, the measurement system should be placed in the box sure to limit to a minimum the influence of Earth's magnetic field. However, making sure from the box will make the higher equipment cost and the quality of the measurement can also be affected. After a period of research and innovation, the group has built and successfully tested a new theory to measure the tiny magnetic fields that do not need to shield from. Costs for equipment used on this principle only by 1/3 compared with the creation screen. For this new principle, the Group is completing application be granted with useful solutions. This is an encouraging result for the team.
To get the complete system equipment can be put to use, researchers have much work to do shrink size of the system, adjust the parameters and to improve the reliability of the system etc. However, with what the team has achieved in the past and especially the passion and creative spirit of them can fully expect that in the near future, a biomedical equipment to measure the biological agents quickly, accurately and conveniently to serve the medical diagnostics, food safety testing, environmental testing, Vietnam manufacturers will be present in the hospital, biomedical laboratories. /.
Source: Office of the State Key Program